What Is KLOW? How It Works + Why I Use This 4-Peptide Blend

What Is KLOW? The Four Peptides Inside It and What Each One Is Actually Doing

KLOW is a combination of KPV, BPC-157, TB-500, GHK-CU. The reason I love KLOW, I actually use it myself.

Before getting into what each piece does, understand what a blend like this is trying to do as a whole. You have four separate compounds, each aimed at a different part of the same problem, which is tissue that is irritated, tissue that is trying to rebuild, and skin that has to hold up while both of those things happen at once.

That last part is where my own experience with it started.

This is the longest I've had my beard in months, maybe years, and the reason I'm able to do it without having that discomfort and the rash that comes is because I've started taking KLOW. I cannot point you to a study on that specific outcome, so take it as one person's result and nothing more.

So KLOW works, it helps with your hair health, skin health, collagen, and then obviously we have the BPC and the TB that are gonna help with inflammation and healing and recovery, and then the KPV, which is also gonna help reduce inflammation. Every one of those effects is what I have seen personally and in the people I work with, and the research hasn't run the trials that would let me say it as fact.

Of the four, KPV is the one with the clearest published story behind it, and it is worth understanding because it explains the logic of the whole blend.

KPV is three amino acids, lysine, proline and valine, and it is the tail end of a larger hormone called alpha-MSH, which is a signaling molecule your body already makes, and it carries two separate instructions folded into one message: it tells pigment cells to make melanin, and it tells immune cells to calm down.

Researchers found that the calming job survives when you cut the molecule down to just those last three amino acids, and alpha-MSH along with its C-terminal fragments suppresses the production of pro-inflammatory signals from immune cells and from skin cells directly, including keratinocytes and fibroblasts, which are the cells that build and maintain skin structure (Luger 2003).

Think of alpha-MSH as a long message with two instructions in it, and KPV as the part of that message that only carries the second instruction. You keep the immune signal and you drop the pigment signal.

That is why KPV shows up in a blend aimed at skin. The receptors it talks to sit on the exact cells that flare up when hair follicles get inflamed.

BPC-157 and TB-500 are the other half of the design, and they are usually paired for the same reason. One is a fragment of a protein found in gastric juice, the other is a fragment of a protein involved in cell movement and structure. In the people I work with they tend to get used during periods of heavy training or after injury, though I have to be straight with you, no study has shown that either one delivers the inflammation and recovery benefits people describe when taken this way.

GHK-CU is a copper-binding peptide, and copper is a required cofactor for enzymes involved in building and cross-linking collagen, so what's happening at the molecular level is well documented and not in question. Whether taking the peptide translates into better skin or better collagen in a person is something the research hasn't settled, so I will tell you only what I have seen.

It's a spectacular combination. I know there are guys out there that talk shit. You shouldn't have the mixes, blah, blah, blah. It fucking works.

Most of what I know about this came out of conversations in the free community, so if you want the rest of it and somewhere to ask, the men's group is here: https://www.skool.com/jh-iron-forge-brotherhood/about

Research: Luger TA, Scholzen TE, Brzoska T et al. New insights into the functions of alpha-MSH and related peptides in the immune system, published in the Annals of the New York Academy of Sciences in 2003.

References

Luger TA, Scholzen TE, Brzoska T et al.. New insights into the functions of alpha-MSH and related peptides in the immune system. Ann N Y Acad Sci. 2003. https://pubmed.ncbi.nlm.nih.gov/12851308/