Do Air Bubbles In Your Syringe Ruin Your Peptides?

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Air Bubbles In Your Peptide Syringe: What They Actually Do

I get white bubbles in the syringe when I draw my peptide. Does that damage it? So basically what happens is when I take my needle and I push it into this solution, whatever you have in your vial, you should have a vacuum or close to a vacuum, meaning inside of the space of this vial is air and whatever liquid, and there's no empty space there.

That vacuum is the whole reason bubbles show up in the first place, so before worrying about the bubbles it helps to understand the pressure system you are working inside of.

A sealed peptide vial arrives with the internal pressure lower than the air in your room. When you pull liquid out and put nothing back in, the pressure inside drops even further, and the vial starts fighting you for every unit you try to withdraw.

And this is also exactly why when you reconstitute and you take that two milliliters of water and you go to put it into your peptide vial, it tries to aggressively suck the water out of the syringe is because there's a vacuum. There's negative space in there pulling.

Ideally, what we wanna do when we're preparing our injection is we actually wanna take air into the syringe, push it into the vial before we draw it.

And what that does is it helps to replace the volume of air that you're extracting so that we don't have this problem with a really big vacuum, okay? If you fail to do that and we don't add the air, what happens is you'll go to draw your syringe and it literally won't pull into the syringe the way that you want it to, or it takes a really long time.

But the downside to that is when I do this and I'm pulling this out, if I go too fast, what could happen is I can pull air bubbles with it, right? Because there's air and liquid inside that vial.

So a couple of things to solve that problem, all you have to do is when you're drawing your syringe, just make sure that the liquid is down, meaning you're drawing it downward rather than upward like this or sideways.

That way all the air is on the top, liquid's on the bottom, we're only drawing the liquid, okay? But if you go too fast, what happens is you create this funnel effect where you can also draw air in.

The mechanical stress worry is real in the lab, and it is worth knowing where it comes from. When human growth hormone and epidermal growth factor were shaken and heated in a stability study, the agitated samples showed measurable aggregation, meaning the protein molecules clumped together instead of staying dissolved, with growth hormone proving more sensitive to the stress than epidermal growth factor (Lim et al., 2015).

Now, too much, I don't think is that big of a problem, but also just keep in mind that because of the nature of peptides, they're very sensitive, and if we're creating too much bubble effect, those bubbles popping, and that's what can potentially break apart those amino acids. I cannot point you to a study that measured bubble collapse in a syringe damaging a peptide, so treat that as caution rather than established fact.

Is it gonna completely render your peptide useless? Probably not, but best practice is to try to draw that with as minimal air into the syringe as possible.

There is a lot more of this inside the women's community, and it costs nothing to be in there, so if you want somewhere to ask the follow-up question it is here: https://www.skool.com/powerhouse-fitness-for-women/about

Research: Lim JY, Kim NA, Lim DG et al. Effects of thermal and mechanical stress on the physical stability of human growth hormone and epidermal growth factor. Arch Pharm Res. 2015.

References

Lim JY, Kim NA, Lim DG et al.. Effects of thermal and mechanical stress on the physical stability of human growth hormone and epidermal growth factor. Arch Pharm Res. 2015. https://pubmed.ncbi.nlm.nih.gov/25430693/