Should You Inject GH Into the Muscle? IGF-1 LR3 vs DES Explained

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Should You Inject GH Into the Muscle? IGF-1 LR3 vs DES Explained

This is actually an interesting question. He said, I heard a podcast that said, GH should be injected IM to the muscle if you wanna grow, is that true or false? This is, I think, a misinterpretation.

To see where the misinterpretation starts, you have to follow the whole chain, because growth hormone does not build muscle directly.

You inject GH, it enters circulation, and the growth hormone most of the time is gonna have to travel to the liver to be converted to IGF-1, which is the molecule that actually signals muscle tissue to grow. Yes, you may have some local conversion that occurs, but that's not the same mechanism that's occurring, right?

So the site you put the needle in is just an entry point to the bloodstream. It is not a delivery address.

Now here is the piece of real science that got scrambled on the way to that podcast. When we do IGF-1-LR3 as an injection, which is the long form, the longer half-life, one of the downsides of using IGF-1-LR3 versus GH is that most of the growth hormone that your body naturally produces for muscle growth specifically is actually produced at the muscle.

So when we use the LR3, we're injecting it systemically, we're not necessarily getting the benefit of that locally produced IGF-1 for the purpose of muscle growth.

That is a real limitation. Somebody heard it and turned it into "inject into the muscle." But the limitation was never about where the needle goes. It was about how long the compound hangs around once it is in you.

Think of it like dye in a swimming pool. If I inject the IGF-1-LR3, it's going to be in my blood for a couple days, so by the time you are actually training, that dye has spread evenly through the whole pool and the corner you dropped it in means nothing.

So injecting in the muscle versus subcutaneous really isn't making that big of a difference in terms of how it's helping you grow the muscle.

There's another type of IGF-1 that you get that has a shorter half-life, which is called IGF-1-DES. And DES actually clears within about 30 minutes of you using it.

Thirty minutes is short enough that the dye never leaves the corner.

And so a lot of times what bodybuilders will do is rather than using the LR3, which creates suppression on the growth hormone axis, we would instead use the DES and inject it locally in the muscle that we plan on training for that day. So if I'm going in and I'm doing arms, we would do boom, boom, or in the tricep or whatever, and that IGF-1-DES is gonna help with that local growth.

And a lot of guys that I know, especially the old school bodybuilders, they love that because the pump that you get while you're using it is freaking insane.

That suppression point matters more than people give it credit for. A compound sitting in your blood for days tells your pituitary that IGF-1 levels are handled, so your own output backs off, and you end up trading your natural production for whatever is in the vial. Something that clears in half an hour does not send that signal nearly as hard.

There are a lot of people that would use growth hormone-related peptides in addition to IGF-1 for short cycles, and they see spectacular results. And I know I've done a lot of videos in the past saying that that's not necessarily something that you have to do.

The better approach would be to just add more GH. Now, there are some people that agree, some people don't agree, but this is where I think that confusion comes from.

So just bear in mind that the approach that you're gonna wanna take if you're doing an IM injection of any growth hormone-related peptide would be specifically for IGF-1-DES.

There is a lot more of this inside the free community, and it is genuinely free, so if you want somewhere to ask the follow-up question the men's group is here: https://www.skool.com/jh-iron-forge-brotherhood/about