How to Keep Insulin Resistance Down After Retatrutide (The Fix)
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How to Keep Insulin Resistance Down After Retatrutide
Best way to keep insulin resistance down and under control when coming off of RETA? Don't eat like an asshole.
That's literally it.
People expect some kind of protocol here, a stack or an add-on compound or a clever taper that protects the metabolic improvements they got while they were on it. And I understand why, because the drug did so much of the work for them that it feels like the solution to losing the drug has to be another drug.
The thing that causes insulin resistance is poor diet, lack of cardiovascular exercise and lack of training and lack of sleep.
Walk the chain for a second so you can see where the drug was actually sitting in it.
Insulin's job is to move glucose out of the blood and into muscle and liver and fat. Muscle is the biggest glucose sink you have, and when muscle cells are already full and surrounded by excess fat, they stop responding well to insulin's signal, so the pancreas pushes out more insulin to get the same job done. That chronically elevated insulin is what we're calling resistance.
Retatrutide improves that by shrinking the amount of fuel coming in, shrinking fat mass, and slowing gastric emptying so glucose arrives in the blood more gradually. It handled your inputs for you without you having to think about them.
When the drug leaves, the inputs come back under your control. Nothing about your cells locked the improvement in, so if the eating and the training go back to what they were before, the insulin resistance follows them back.
So if you go back to episode one of the first video Josh ever did on any peptide at the end, I said these are great, but you need to make sure you optimize your foundations, which comes down to sleep, food and training, and none of that changes no matter what compound you're running.
Sleep is number one, and I put it there for a reason. Poor sleep raises cortisol, and cortisol tells the liver to dump glucose into the blood at the exact moment your muscle is least interested in taking it. You can eat perfectly and still be fighting that every morning.
Food comes second, and when it comes to food, you need to be making sure that you're eating a sufficient amount of whole food, protein specifically, get enough healthy fats in and stick to your healthy carbs and always make sure you're getting enough fiber.
Protein keeps the muscle you held onto during the run, and muscle is the tissue that disposes of glucose, so if you let that muscle go, the storage space goes with it.
Fiber slows how fast glucose hits the bloodstream, which is one of the same jobs the drug was doing through delayed gastric emptying. A crude replacement, but the right direction.
As far as your training is concerned, you should be doing some type of high-incense the interval cardio at least twice per week. Sometimes I would, and for most people, I suggest three and always try to get at least some type of, you know, at least 7,000, 8,000 steps per day.
Intervals work here specifically because hard contractions pull glucose into muscle through a pathway that doesn't need insulin at all, and that effect lasts well past the session.
The steps matter for a separate reason, which is that long stretches of sitting suppress glucose uptake on their own, regardless of what you did in the gym that morning.
Resistance training sits underneath both, because every pound of muscle you add is more room to put glucose.
None of this is new and none of it is clever. It's the same list that was true before you ever touched a peptide.
There is a lot more of this inside the free community, and it is genuinely free, so if you want somewhere to ask the follow-up question the men's group is here: https://www.skool.com/jh-iron-forge-brotherhood/about
If this is the kind of information you want access to on a daily basis, the community is free and there are full courses on training, nutrition, hormones, and supplementation inside. You can ask questions and post your own labs and get feedback from me and from the community.