Does Enclomiphene Lower Your IGF-1? (How to Compensate)

Watch the full video on Rumble: https://rumble.com/v7h8e14-does-enclomiphene-lower-your-igf-1-how-to-compensate.html

Does Enclomiphene Lower Your IGF-1, and How Much Growth Hormone Compensates?

Enclomiphene can lower how much of your growth hormone gets converted into IGF-1, because the liver uses estrogen signaling to run that conversion. So the question that this gentleman asked, and it's in reference to a video I did a couple months ago about enclomiphene or serms reducing your IGF-1 conversion, is a fair one. The answer is lab work first, then one to two IUs of GH per day.

Before the detail, walk the chain.

Your pituitary releases growth hormone in pulses, mostly at night, and that growth hormone travels to the liver, and the liver reads the signal and then produces IGF-1, which is the molecule that actually does most of the work people credit to GH. Tissue repair, collagen turnover, lean mass. So IGF-1 is the output you care about, and the liver is the factory that makes it.

So for context, what we found after doing research is that when we suppress your body's ability to detect that E2, which is basically what the serms do to influence your body and reduce more testosterone, it could also have a negative effect of conversion of HGH to IGF-1 at the liver because your liver needs that estrogen to convert it.

In plain terms, estrogen receptor activity inside liver cells helps keep the growth hormone signal running cleanly through the chain of proteins that carries the GH message to the gene that makes IGF-1. A SERM sits on estrogen receptors and blocks them in some tissues, and the liver is one of those tissues, so the message still arrives but gets read at a lower volume.

Think of a factory that has all its raw material on the loading dock but somebody turned down the lights on the production floor. The GH is there. The conversion rate drops.

So the question now becomes, okay, well, if enclomiphene reduces my IGF-1 conversion, how much more of these growth hormone related peptides do I need to add in order to compensate for that? And that's actually a great question.

I'm just going to preface this answer with the only way to truly know is to get your lab work done.

I lead with that instead of a dose because the size of the effect varies a lot between people, and it tracks with your baseline IGF-1, your age, your liver health, your enclomiphene dose and how long you have been running it. Two guys on the same protocol can land in very different places, and no dosing rule written on the internet tells you which one you are.

You should be getting your IGF-1 checked, see where that's at, and that's going to give you the answer you're looking for. Pull it alongside your testosterone and estradiol so you see the whole picture at once. IGF-1 is the right marker here because it stays fairly stable across the day, while GH itself pulses and a single draw tells you almost nothing.

Once you have a number, you have a target. If your IGF-1 sits low in the reference range while you are running a full protocol, the loss is happening at the conversion step, and that is where you intervene.

But in my mind, adding one to two IUs of GH per day is still going to have a meaningful increase on your IGF-1 conversion, even if you're on enclomiphene. The blunting is partial, not total, so you are not pushing against a closed door, you are pushing against a stiffer one, and more input still moves the output.

Start at the low end, run it eight to twelve weeks, and retest. If IGF-1 moved where you want it, stay there. If it barely moved, that is information too, and it points you back at the enclomiphene dose rather than at stacking more GH on top of a blocked signal.

Most of what I know about this came out of conversations in the free community, so if you want the rest of it and somewhere to ask, the men's group is here: https://www.skool.com/jh-iron-forge-brotherhood/about